2022-06-21
BSG antibodies have transendothelial cell drug delivery capability
The blood-brain barrier (BBB) poses a challenge to antibody-based brain therapies and is a major barrier to the successful application of biotherapeutics in the treatment of brain diseases. Since only a small percentage of monoclonal antibodies (mAbs) are able to penetrate the blood-brain barrier, large doses of therapeutic drugs are required to elicit drug effects.
2022-05-20
IL-17 stimulation induces NOTCH1 activation in OPC, leading to Th17-mediated demyelinating disease
Multiple sclerosis is a disease of central nervous demyelination that is more common in Western countries and is increasing in number in China every year. The disease is usually characterized by a remitting, relapsing course, with a predilection for the optic nerve, spinal cord and brainstem. There is no better treatment for this disease, and the available drugs can only alleviate and slow down the disease process.
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