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Susceptibility of exosomes secreted by cardiomyocytes to inhibit tumor iron death in ischemic heart failure

Time：

2023-05-16

Exosomes Secreted from Cardiomyocytes Suppress the Sensitivity of Tumor Ferroptosis in Ischemic Heart Failure

　　Exosomes Secreted from Cardiomyocytes Suppress the Sensitivity of Tumor Iron Death in Ischemic Heart Failure

　　Exosomes Secreted from Cardiomyocytes Suppress the Sensitivity of Tumor Ferroptosis in Ischemic Heart Failure

　　It has been shown that cardiac remodeling and heart failure significantly accelerate the progression of swelling and pain. For refractory tumors, targeting iron death may be a promising therapeutic strategy. Meanwhile, exosomes play a key role in regulating disease in a paracrine manner. However, whether exosomes modulate cancer sensitivity to iron death by regulating cardiomyocyte-tumor cell crosstalk in ischemic heart ho is unclear. This study reveals for the first time that myocardial infarction enriches exosomes and thereby inhibits erastin (iron death broad inducer)-induced iron death in tumor cells through the release of miR-22-3p from cardiomyocytes. Thus, targeting the exosome-mediated pathological link between cardiomyocytes and tumors may provide a new avenue for iron death-based antitumor therapy.