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Light regulates glucose metabolism via the retina-hypothalamus-brown adipose tissue axis

Time：

2023-06-14

Liaht modulates alucose metabolism by a retina-hypothalamus-brown adipose tissue axis

　　Light regulates alucose metabolism by a retina-hypothalamus-brown adipose tissue axis

　　Liaht modulates alucose metabolism by a retina-hypothalamus-brown adipose tissue axis

　　Artificial light exposure is one of the important factors that induce metabolic diseases. In this study, we found that light exposure can rapidly reduce glucose tolerance (GT) in mice by activating autoreceptor retinal ganglion cells (ipRGCs) that innervate the supraoptic nucleus (SON) of the hypothalamus. After the loop, the effect of light on glucose metabolism can be interrupted in the dark environment, after the small rest receives a pencil coding injection, causing heat production in the drop-colored eye fat tissue. However, the light package phase interrupts this active stress thermogenesis process reducing capacitive glucose tolerance (GT, this study provides a potential preventive and therapeutic strategy for glucose metabolism disorders.

　　 w10

　　IF66.85

Author Affiliation.

　　Department of Life Sciences and Medicine, University of Science and Technology of China

　　Published in:Cell

　　DOI:10.1016/i.cell.2022.12.024

　　Product index & item number:EPI(Epinephrine/Adrenaline) ELISA Kit(E-EL-0045c)

　　NA/NE(Noradrenaline/Norepinephrine)ELISA Kit(E-EL-0047c)、Mouse OXA(Orexin A)ELISA Kit(E-EL-M0860c)、Mouse GHRL(Ghrelin) ELISA Kit(E-EL-M0551c)、Mouse GC(Glucagon) ELISA Kit(E-EL-M0555c)、Mouse GH(Growth Hormone)ELISA Kit(E-EL-M0060c)Non-esterified Free Fatty Acids(NEFA/FFA)Colorimetric Assay Kit(E-BC-K013-S)，L-Lactic Acid(LA) Colormetric Assay Kit(E-BC-K044-M)