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Rod-shaped nanoparticle polymers interfere with neutrophils for effective treatment of ischemic stroke
Time：
2023-06-14
Rod-Shaped Polymeric Nanoparticles Intervene Neutrophils for Efficient Ischemic Stroke Therapy
Rod-Shaped Polymeric Nanoparticles Intervene Neutrophils for Efficient Ischemic Stroke Therapy
Rod-Shaped Polymeric Nanoparticles Intervene Neutrophils for Efficient Ischemic Stroke Therapy
Neutrophils are involved in the pathophysiological process of ischemic stroke, and prevention of neutrophil infiltration into the cerebral ischemic zone is a potential therapeutic approach. In this study, a rod marrying infant glycolic acid (PLGA) nanoparticle was developed to target the interaction of neutrophils with inflammatory endothelial cells. It was shown that AR5 nanoparticles loaded with picopitanol (Pic@AR5) blocked the adhesion of neutrophils to endothelial cells and inhibited neutrophil infiltration of the blood-brain barrier (BBB). Even if a small fraction of Pic@AR5 carries neutrophils to speak into the blood-brain barrier, the nanoparticles can release piperitinol in the bell blood region and inhibit microglia Svk signaling, thus alleviating neurological capitalism. The strategy provided in this study provides a new direction for the treatment of ischemic stroke.
IF19.924
Author Affiliation.
Institute of Biomedical Engineering, Southwest Jiaotong University School of Medicine
Published in:AdvancedFunctionalMaterials
DOI:10.1002/adfm.202212326
Product index & item number:PE/Cyanine5.5 Anti-Mouse CD45 Antibody(E-AB-F1136)10xRBC Lvsis/Fixation Solution(E-CK-A106)
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