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DNA-dependent protein kinase catalytic subunit (DNAPKcs drives chronic kidney disease progression in male mice
Time：
2023-05-16
DNA-dependent protein kinase catalytic subunit(DNA-PKcs) drives chronic kidney disease progression in malemice
DNA-dependent protein kinase catalytic subunit (DNAPKcs) drives chronic kidney disease progression in male mice
DNA-dependent protein kinase catalytic subunit (DNA-PKcs) drives chronic kidney disease progression in malemice
Renal injury triggers epithelial dedifferentiation and fibroblast activation during the progression of chronic kidney disease. The expression of DNA-PKcs is significantly increased in the renal tissue of both patients with unilateral ureteral obstruction and unilateral ischemia-reperfusion-induced wanton kidney disease and male mice, and knockdown of DNA-PKCS or treatment with its specific inhibitor NU7441 hinders the development of chronic kidney disease in male mice.TAF7 may act as a DNA-PKcs substrate by upregulating the expression of RAPTOR to promote the activation of mTORC1 and regulate the metabolism of damaged epithelial cells and fibroblasts. Inhibition of DNAPKcs could be a potential target for the treatment of chronic kidney disease.
IF17.694
Author Affiliation.
Nanjing Medical University Children's Hospital
Published in:NatureCommunications
DOI:101038/41467-023-37043-5
Product index & item number:L-Lactic Acid(LA) Colorimetric Assay Kit(E-BC-K044-M)
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